Ameliorative Effect of Omega-3-Rich Fish Diet on the Neurotoxic Effects of Propionic Acid in a Rodent Model of Autism

Despite the increased social and financial burden associated with autism spectrum disorder (ASD), no particular treatment for this illness has been identified. A detailed examination of prior trials conducted to treat revealed that nutrition intervention was commonly utilised as an additional method therapy. Indeed, early detection nutritional deficiencies metabolic problems, together appropriate therapeutic measures, can be a cornerstone enhancing behavioural abilities individuals autism. In work, propionic acid (PPA)-induced rodent model ASD fed Spangled emperor (Lethrinus nebuloses), Dusky grouper (Epinephelus marginatus), Parrot Fish (Scaridae), which are locally named Hammour, Shour, Hareed, respectively, in Saudi Arabia. The aim study investigate effect dietary three kinds whole fish nebuloses, Epinephelus marginatus, Scaridae), rich source ω-3 fatty acids, on selected biochemical markers (reduced glutathione (GSH), thiobarbituric reactive substances (TBARS), creatine kinase (CK), lactate dehydrogenase (LDH), dopamine) histopathological cerebellum hippocampus neurotoxic features Briefly, our findings give preliminary evidence favour employing supply omega-3 acids reduce PPA-induced rat model. It may beneficial provide extra marine omega-3-rich diet improving certain autistic related oxidative stress, energy metabolism, brain neurotransmitters.